NAD⁺ is involved in the electron transport chain, which is the process by which cells generate energy in the form of ATP. NAD⁺ levels decline with age and this has led to the hypothesis that NAD⁺ is a key regulator of the aging process, with some studies suggesting that healthy NAD⁺ levels are a critical factor for cell survival with low levels associated with a variety of health problems, including insulin resistance, fatigue, inflammation, poor stress resistance and neurodegeneration.

NAD⁺ serves as the main substrate for the sirtuins to perform their enzymatic activity, with sirtuins having shown to regulate gene expression, improve insulin sensitivity, reduce inflammation, protect against age-related diseases, with some research even suggesting that sirtuins may play a role in regulating the aging process itself.


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